Hopkins inHealth Request for Pilot Proposals
The mission of Hopkins inHealth is to support research that will, with increasing accuracy and precision, define, measure, and communicate each person’s unique health state and the trajectory along which it is changing, and to develop these discoveries into new methods that can be used to inform decision-making in clinical and public health practice. The goal of this individualization of health care is to reach a state of optimal health for every individual, achieved through a continuum of efforts that span health promotion, disease prevention, early detection, and effective intervention.
Hopkins inHealth is seeking proposals for pilot projects that will promote optimal health trajectory, treatment safety, and treatment efficacy for individuals in several domains, including 1) the creation or identification of novel devices, platforms, technologies, analytics, or biomarkers that will lead to more nuanced measurements of health or disease status, 2) the development of novel quantitative methodologies that integrate data to better understand patient heath status, predict patient outcomes, and/or recommend treatment course, 3) the innovative incorporation of scientific knowledge and individualized care into the clinical workflow, and 4) the research of ethical questions regarding consent and use of personal data. The goal of the pilot project discovery program is to fund projects that can be implemented within Johns Hopkins as proof of concept before widespread implementation.
Pilot Project Criteria:
We seek to fund projects in any health or disease context that meet the following criteria:
- Individualizes health care by improving the characterization of health status, health trajectory, or the benefits and costs of interventions through achieving one or more of the following:
- Improves the assessment of an individual’s health or disease state and/or trajectory through novel measurement methodologies, devices, platforms or technologies (visit the Measurement Core page to learn more);
- Devises a new quantitative methodology that improves the characterization of an individual’s disease state, predicts the likelihood of a health outcome, recommends the optimal treatment for an individual, or efficiently incorporates new knowledge into care delivery or public health practice;
- Determines ethical methods for gaining patient consent for use of health data in learning health systems;
- Evaluates the effects of individualized health care in defined populations; 
- Specifies a defined and attainable goal within the expected timeframe (see the “Eligibility and Award Information” section below);
- Stands ready to be refined or scaled up with involvement from Hopkins inHealth experts in novel measurements, longitudinal database design, novel analytics, bioethics, and dissemination models;
- Addresses health disparities, unmet medical needs, or diseases with high public health or economic burdens;
- Generates data, knowledge, software, or technology for the investigators to use in pursuit of additional research funding and to publish in the peer-reviewed literature;
- Builds or strengthens connections between existing Johns Hopkins entities (e.g., schools, centers, institutes), including the Johns Hopkins Health System and APL, and supports one or more of their strategic objectives (e.g. see JHM Priorities);
- Demonstrates potential to advance affordable health care for individuals and populations.
Eligibility and Award Information:
Up to $500,000 will be invested in this pilot program. We seek grant applications requesting up to $75,000 for 15 months. A small number of the most exciting ideas will be awarded up to $100,000. All projects will be required to submit a one-page final report after completion.
Expectations of funding include the presentation of project progress at a Hopkins inHealth seminar and the potential for external funding application based upon the preliminary work.
The engineering and consulting firm Booz Allen Hamilton will collaborate with one of the pilot projects. The pilot project criteria and scoring guidelines are the same for proposals considered for Booz Allen Hamilton funding as for proposals considered only for Johns Hopkins funding. See the Applications Materials section for more detail on how to be considered for funding by Booz Allen Hamilton.
Principal Investigators (PIs) must be faculty members of the Johns Hopkins University, the Johns Hopkins Health System, or staff at the Applied Physics Laboratory. We especially welcome proposals that include PIs and Co-PIs who are in the early stages of their careers.
Membership in Hopkins inHealth is an eligibility requirement for all Hopkins inHealth funding opportunities. It takes two minutes to become a member; visit http://hopkinsinhealth.jhu.edu/join-us to apply. Members receive up-to-date information on individualized health news and grant opportunities; invitations to inHealth events; and access to a network to individuals engaged in cutting-edge individualized health research. Membership applications must be submitted by October 23rd to be eligible for this opportunity.
Scoring Guidelines: An internal group from Johns Hopkins University, Health System and Applied Physics Laboratory will assess Proposals in terms of their consistency with the Pilot Project Criteria.
A completed application must comprise the elements listed below. The body of the proposal (elements 2-4 below) must be three pages or less.
1. Cover letter from the PI: This section should be written for a non-technical reader and should include the title and a brief summary of the project goals, expected contributions, and how the project meets the “Pilot Project Criteria.” To be considered for Booz Allen Hamilton funding, include the following statement in bold at the end of the cover letter: “I wish to be considered for funding by both Johns Hopkins and Booz Allen Hamilton.”
2. Specific Aims: This should be a succinct statement of the aims and anticipated outcomes of the proposal.
3. Significance: This should be a concise description of relevant background information and significance of the proposed project.
4. Approach: This includes the research design, measures, data analysis plan, and any preliminary data. (Graphs and/or diagrams may be placed in an appendix and will not be counted towards the page limit.)
5. Budget and Budget Justification for Year 1 and Year 2: This should include PI and Co-PI effort (whether funding is requested for this or not), other personnel, and equipment/materials/supplies. Faculty salary can be included, but funding for this will not exceed 20% effort (including fringe). Use NIH budget forms PHS 398 (Form Page 4 and Page 5). Funding is expected to start in January 2016. (Limit to two pages; the budget and budget justification is not counted towards the overall page limit.)
6. Biographical Information: For PI(s), Co-PI(s), and other Key Personnel, submit a biosketch showing qualifications to successfully complete the proposed project. Use NIH PHS 398 biographical sketch format page (Limit to four pages per person; biographical information is not counted towards the overall page limit.)
Application Deadline and Timeline for Review:
Applications are due no later than October 23, 2015 by 11:59 p.m. Eastern Time and should be submitted as a single PDF document to firstname.lastname@example.org. Proposals will be evaluated by a panel of Johns Hopkins experts in relevant areas of biomedical and data sciences, healthcare, and dissemination potential. Funding decisions are expected by December 15, 2015. Projects are expected to start on January 1, 2016.
For scientific or administrative questions, email Bahar Zarrabi at email@example.com.
 Proposals that do not fall into these categories but have the potential to individualize health are welcome.