Measurement Corps

The Measurement Corps identifies unmet clinical measurement needs, then develops and disseminates tools designed to meet these needs. The core provides expertise in the development of point-of-care devices to measure analytes and biomarkers from patient samples, wearable sensors for real-time monitoring of health state, and molecular imaging techniques for non-invasive visualization inside the body. These measurements will provide the basis for meta-analysis within specific disease types, laying a foundation for improved clinical decisions.

 

Core services include:

  • Meeting with clinicians and primary care providers to identify measurement needs that will improve medical decision-making
  • Building a measurement portal to catalog the state-of-the-art and to develop target specifications

 

Measurement Corps Areas of Interest:
The development or refinement of point-of-care assays and devices. Point-of-care devices provide data on analytes and biomarkers from patient samples. The Measurement Corps will support projects that seek to refine existing measurement devices and is especially interested in enhancements that will lower costs, reduce measurement times, or improve sensitivity. The Corps also seeks to facilitate the development of new point-of-care biomarkers and assays, including ones that will provide rapid assessment of the protein and gene content of bodily fluids.


Innovative new applications for existing sensors. Many sensor technologies can be repurposed for applications in individualized health. For example, wearable fitness sensors that record and transmit data are increasingly used to provide insight into patient health status in a wide range of settings. The current state-of-the-art in wearable sensors includes the measurement of vital signs (body temperature, pulse, respiration breathing rate, blood pressure), movement, sweat (conductivity), and electroencephalogram (EEG). The Measurement Corps supports projects that will enable existing sensors to 1) record chemical, biochemical, and other physiological data relevant to medical conditions and 2) provide real-time feedback that can be used to improve health care.
 

Molecular Imaging.  Molecular imaging refers to a family of non-invasive imaging methods that allow visualization of cellular processes. Specifically, it depicts biochemistry rather than anatomy, which is the purview of standard imaging methods, such as computed tomography and magnetic resonance imaging. Examples of molecular imaging techniques include positron emission tomography and optical imaging with targeted fluorescent contrast agents. Because it enables the visualization of biochemistry, molecular imaging is inherently more sensitive and can be more specific than standard medical imaging. It can, for instance, show the effect of a chemotherapeutic agent on a tumor weeks or months before any anatomic change can be detected on conventional imaging. Molecular imaging agents and techniques can be customized to identify a specific molecular target and therefore lend themselves perfectly to individualized medicine. The Measurement Corps will support the development of molecular imaging agents and techniques that can be used, for example, to choose the correct patients for a phase I trial for a new therapeutic agent, to prove that a new targeted drug is indeed on target, or to study the biochemistry of a variety of processes, including cell trafficking or receptor internalization in patients.   

 

To consult the Measurement Corps, submit a request here. A Johns Hopkins ID is required to log-in.

More information on how to submit a request can be found on the Johns Hopkins Institute for Clinical and Translational Research website.

Questions? Contact Dr. Peter Searson at searson@jhu.edu.

For information on postdoc positions with the Measurement Corps, visit our Employment Opportunities page.

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